Alzheimer's disease, in the vast majority of cases, is a multifactorial syndrome associated with various risk factors present throughout our lives. Metabolic alterations and dysfunction in cerebral glucose metabolism are widely reported, even from the early stages of the disease. Recently, it has been postulated that the intestinal microbiota may also play an essential role in the pathogenesis of Alzheimer's since the presence of certain bacteria is associated with an increased risk of developing dementia. Diet can strongly modulate both metabolic alterations and the intestinal microbiota.
In the laboratory, we have been exploring the impact of diets rich in bioactive and prebiotic foods on brain function within the so-called microbiota-gut-brain axis. We have been able to determine that by changing the intestinal ecology with the intake of various foods, the release of microbial products is modulated, thus improving cognitive function and preventing neurodegeneration in transgenic models for Alzheimer's disease and diet-induced obesity models. These data indicate, on the one hand, that the intake of some foods could prevent the appearance of cognitive damage in advanced ages. On the other, it highlights the importance of our microbiota in developing neurodegenerative diseases.
Another line of research we have extensively developed is the characterization of the common marmoset, a non-human primate, and the tree shrew, a scadentia, as models of aging with neurodegeneration. These models have the great advantage of presenting a genomic sequence closer to humans and a more complex brain structure and cognitive development compared to rodents. Furthermore, they present various cellular and functional alterations that position them as ideal models for understanding the fine line that divides normal aging from neurodegeneration.
Estudio de la Disfunción del Estroboloma durante la Perimenopausia como Factor de Riesgo para Desarrollar Alzheimer