Recent findings

Search

Search

Menu

José Vázquez Prado Ph.D. Selected references Recent findings Students Staff Alumni Pictures Lab Signaling Pathways Spanish Version

January, 2020

Our paper: “cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits” has been selected as the representative ‘Signal transduction’ article for the 2019 retrospective collection called “The year in JBC: 2019.” According to the communication received: "The associate editors looked through hundreds of papers to come up with what they felt best represented the exciting advances reported in JBC last year" The special issue can be found at http://www.jbc.org/site/vi/.

Recent findings

G protein coupled receptors regulate mTOR signaling through direct interactions between this fundamental kinase and Gβγ. These findings provide further support to emerging strategies based on the therapeutical potential of inhibiting different Gβγ signaling interfaces.

P-Rex1 is a key element in SDF-1-induced angiogenic responses and a potential target for therapeutic intervention.

Sphingosine-1-Phosphate receptor S1P(1) signaling, linked to cell migration, is facilitated by a functional interaction with P-Rex1, via a mechanism that involves the maintenance of S1P(1) receptors at the cell membrane.

The assembly and signaling of mTORC1 is positively regulated by GRp58/ERp57.

We discovered a novel mechanism by which mTORC2 controls the activation of Rho GTPases by virtue of its ability to form molecular complexes with P-Rex1. Via this pathway, mTORC2 activates Rac signaling, leading to cell migration.

A Phosducin-like protein derived peptide is a suitable tool to differentially modulate the Gbetagamma-initiated pathway linking this heterodimer to AKT, endothelial cell migration, and in vitro angiogenesis. It can be also useful to further characterize the molecular determinants of the Gbetagamma-PI3Kgamma interaction.