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  • 24 / 11 / 2017
Cinvestav - Centro de Investigación y de Estudios Avanzados del I.P.N.

Publicaciones representativas

Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J.
J Biol Chem. 2016 Mar 18;291(12):6182-99. doi: 10.1074/jbc.M115.712216. Epub 2016 Jan 21.

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Hernández-García R, Iruela-Arispe ML, Reyes-Cruz G, Vázquez-Prado J. Vascul Pharmacol. 2015 Oct 17. pii: S1537-1891(15)00220-7. doi: 10.1016/j.vph.2015.10.003.


Gβγ interacts with mTOR and promotes its activation. Robles-Molina E, Dionisio-Vicuña M, Guzmán-Hernández ML, Reyes-Cruz G, Vázquez-Prado J. Biochem Biophys Res Commun. 2014 Jan 22. pii: S0006-291X(14)00068-0. doi: 10.1016/j.bbrc.2014.01.044

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. Nat Rev Cancer. 2013 Jun;13(6):412-24

Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Ramírez-Rangel I, Bracho-Valdés I, Vázquez-Macías A, Carretero-Ortega J, Reyes-Cruz G, Vázquez-Prado J. Mol Cell Biol. 2011

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor. Ledezma-Sánchez BA, García-Regalado A, Guzmán-Hernández ML, Vázquez-Prado J. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1647-52.

Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. Carretero-Ortega J, Walsh CT, Hernández-García R, Reyes-Cruz G, Brown JH, Vázquez-Prado J. Mol Pharmacol. 2010 Mar;77(3):435-42.

Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. Guzmán-Hernández ML, Vázquez-Macías A, Carretero-Ortega J, Hernández-García R, García-Regalado A, Hernández-Negrete I, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. J Biol Chem. 2009 Jul 3;284(27):18334-46.

G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. García-Regalado A, Guzmán-Hernández ML, Ramírez-Rangel I, Robles-Molina E, Balla T, Vázquez-Prado J, Reyes-Cruz G. Mol Biol Cell. 2008 Oct;19(10):4188-200.

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. J Biol Chem. 2007 Aug 10;282(32):23708-15.


Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. Vázquez-Prado J, Miyazaki H, Castellone MD, Teramoto H, Gutkind JS. J Biol Chem. 2004 Dec 24;279(52):54283-90.

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. Rosenfeldt H, Vázquez-Prado J, Gutkind JS. FEBS Lett. 2004 Aug 13;572(1-3):167-71.

Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind JS. J Biol Chem. 2004 Feb 13;279(7):6182-9.

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. Perrot V, Vazquez-Prado J, Gutkind JS. J Biol Chem. 2002 Nov 8;277(45):43115-20.

Potent activation of RhoA by Galpha q and Gq-coupled receptors. Chikumi H, Vázquez-Prado J, Servitja JM, Miyazaki H, Gutkind JS. J Biol Chem. 2002 Jul 26;277(30):27130-4

Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts. Vázquez-Prado J, Medina LC, García-Sáinz JA. J Biol Chem. 1997 Oct 24;272(43):27330-7.

Effect of phorbol myristate acetate on alpha 1-adrenergic action in cells expressing recombinant alpha 1-adrenoceptor subtypes. Vázquez-Prado J, García-Sáinz JA. Mol Pharmacol. 1996 Jul;50(1):17-22.

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